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Additional file 1 of Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study

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Bull, Caroline J.;Bell, Joshua A.;Murphy, Neil;Sanderson, Eleanor;Davey Smith, George;Timpson, Nicholas J.;Banbury, Barbara L.;Albanes, Demetrius;Berndt, Sonja I.;Bézieau, Stéphane;Bishop, D. Timothy;Brenner, Hermann;Buchanan, Daniel D.;Burnett-Hartman, Andrea;Casey, Graham;Castellví-Bel, Sergi;Chan, Andrew T.;Chang-Claude, Jenny;Cross, Amanda J.;de la Chapelle, Albert;Figueiredo, Jane C.;Gallinger, Steven J.;Gapstur, Susan M.;Giles, Graham G.;Gruber, Stephen B.;Gsur, Andrea;Hampe, Jochen;Hampel, Heather;Harrison, Tabitha A.;Hoffmeister, Michael;Hsu, Li;Huang, Wen-Yi;Huyghe, Jeroen R.;Jenkins, Mark A.;Joshu, Corinne E.;Keku, Temitope O.;Kühn, Tilman;Kweon, Sun-Seog;Le Marchand, Loic;Li, Christopher I.;Li, Li;Lindblom, Annika;Martín, Vicente;May, Anne M.;Milne, Roger L.;Moreno, Victor;Newcomb, Polly A.;Offit, Kenneth;Ogino, Shuji;Phipps, Amanda I.;Platz, Elizabeth A.;Potter, John D.;Qu, Conghui;Quirós, J. Ramón;Rennert, Gad;Riboli, Elio;Sakoda, Lori C.;Schafmayer, Clemens;Schoen, Robert E.;Slattery, Martha L.;Tangen, Catherine M.;Tsilidis, Kostas K.;Ulrich, Cornelia M.;van Duijnhoven, Fränzel J. B.;van Guelpen, Bethany;Visvanathan, Kala;Vodicka, Pavel;Vodickova, Ludmila;Wang, Hansong;White, Emily;Wolk, Alicja;Woods, Michael O.;Wu, Anna H.;Campbell, Peter T.;Zheng, Wei;Peters, Ulrike;Vincent, Emma E.;Gunter, Marc J.

Description

Additional file 1: Table S1. Genetic variants used to instrument BMI, WHR and metabolites. Table S2. Assesment of instrument strength. Table S3. Colorectal cancer case distributions by study, sex and site. Table S4. LogOR colorectal cancer per SD higher BMI or WHR. Table S5. Beta change in NMR-detected metabolite per SD higher BMI or WHR. Table S6. LogOR colorectal cancer per SD higher BMI or WHR-driven NMR-detected metabolite. Table S7. Risk of overall colorectal cancer per SD higher adipose or metabolite trait, estimated using multivariable Mendelian randomization. Table S8. Posthoc investigations.

Citations (0)

Mentions (0)

Metrics

Dataset Index

0.7

FAIR Score

85%

Citations

1

Mentions

0

Metrics Over Time

Publication Details

DOI

10.6084/m9.figshare.13466701

Publisher

figshare

License

Creative Commons Attribution 4.0 International

Assigned Domain

Subfield

Cancer Research

Field

Biochemistry, Genetics and Molecular Biology

Domain

Life Sciences

Confidence Score

98%

Source

Open Alex

Keywords

BiochemistryMedicineCell BiologyGeneticsFOS: Biological sciencesMolecular BiologyPhysiologyBiotechnologyEvolutionary BiologyChemical Sciences not elsewhere classifiedSociologyFOS: SociologyImmunologyFOS: Clinical medicineBiological Sciences not elsewhere classifiedCancerComputational Biology

Normalization Factors

FT

76.92

CTw

1.00

MTw

1.00